In vitro anticoagulant activity of different processed products of Whitmania pigra by water extraction and bionic extraction
Processing study published in China Journal of Chinese Materia Medica (2016)
Abstract
In order to determine the scientificalness of traditionally processed Whitmania pigra, water extraction method and bionic extraction method were used respectively to extract the anticoagulating active components in W. pigra hanging dry products, talcum powder fried products and wine immersing-baked products. Activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), and antithrombin activity were selected as the activity indexes to evaluate the anticoagulant activities of different processed W. pigra. Then the contents of protein in different processed W. pigra were measured by Coomassie brilliant blue method to preliminarily explain the reason of anticoagulant activity changes. When water extraction method was used, the results of APTT, PT, TT and antithrombin activity showed that the anticoagulant activities of W. pigra were decreased both in talcum powder fried products and wine immersing-baked products, and the activity order was as follows: hanging dried products> wine immersing-baked products>talcum powder fried products. This order was same as the protein content order. While when bionic extraction was used, APTT was shortened in talcum powder fried products, but all the other results indicated the anticoagulant activities of W. pigra processed products were increased, and the activity order was as follows: wine immersing-baked products>talcum powder fried products>hanging dry products. As compared with water extraction, the bionic extraction was more similar to the absorption process of W. pigra in human digestive system after oral administration and was more scientific. Therefore, the traditional processing method can not only modify the taste and smell, but also enhance the anticoagulant activity of W. pigra.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Compares water extraction vs simulated-gastric bionic extraction of Whitmania pigra — bionic extraction yields higher anticoagulant activity per gram of raw material.
Por qué esto importa para la hirudoterapia
Este estudio evaluó las actividades anticoagulantes in vitro de diferentes productos de Whitmania pigra tradicionalmente procesados (secado por suspensión, frito con polvo de talco y horneado por inmersión en vino) utilizando tanto extracción acuosa como métodos de extracción biónica (gastrointestinal simulada), midiendo APTT, TP, tiempo de trombina y actividad antitrombina. La extracción acuosa mostró una actividad anticoagulante disminuida en los productos procesados (secado por suspensión > horneado en vino > frito), mientras que la extracción biónica mostró una actividad aumentada en los productos procesados (horneado en vino > frito > secado por suspensión), señalando los autores que la extracción biónica simula mejor la absorción oral. Esto es relevante para la hirudoterapia y la medicina tradicional basada en sanguijuelas, ya que aporta evidencia para optimizar los métodos de preparación con el fin de maximizar la potencia terapéutica. Sin embargo, el estudio se limita a ensayos de coagulación in vitro y mediciones del contenido proteico; ningún dato farmacocinético, in vivo o clínico confirma que los resultados de la extracción biónica se traduzcan en desenlaces terapéuticos.
Citación
In vitro anticoagulant activity of different processed products of Whitmania pigra by water extraction and bionic extraction.
Shan Y et al. · Zhongguo Zhong yao za zhi, 2016
Contexto clínico relacionado
Explore cómo esta investigación se conecta con la práctica clínica
Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: 18 de junio de 2026