Tissue factor/TFPI and blood cells.
Review published in Thrombosis research (2011)
Abstract
Vascular injury-induced access of blood to tissue factor (TF) leads to the formation of a TF-FVII/FVIIa complex and the triggering of blood coagulation. The activated TF-dependent pathway is regulated by Tissue Factor Pathway Inhibitor (TFPI), which binds and inhibits FXa, but more importantly forms an inactive quaternary complex with TF-FVIIa-FXa, effectively shutting off the TF activity. The old view of TF residing in extravascular sites exclusively has recently been challenged by several reports on TF expression in various blood cells. The latter arena has unfortunately been marred by many contradictions, apparently related to inferior tools and/or study design, notably the widespread use of antibodies with inferior and misleading specificity and TF activity assays of low sensitivity/specificity. Our own studies along with many other reports, compels the conclusion that in blood of healthy individuals TF is exclusively associated with and expressed in circulating monocytes. In this short review the distribution of TF and TFPI in blood is discussed.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
Vascular injury-induced access of blood to tissue factor (TF) leads to the formation of a TF-FVII/FVIIa complex and the triggering of blood coagulation. The activated TF-dependent pathway is regulated by Tissue Factor Pathway Inhibitor (TFPI), which binds and inhibits FXa, but more importantly...
Por qué esto importa para la hirudoterapia
Esta revisión discutió la distribución del factor tisular (TF) y del inhibidor de la vía del factor tisular (TFPI) en células sanguíneas, concluyendo que en individuos sanos el TF se asocia exclusivamente con monocitos circulantes, mientras señaló contradicciones en la literatura previa debido a anticuerpos y ensayos de calidad inferior. La relevancia para la ASH es periférica: el resumen aborda la iniciación y regulación de la coagulación pero no involucra sanguijuelas, hirudina ni moléculas derivadas de la sanguijuela. Advertencia: sin participación de sanguijuelas; relevancia indirecta únicamente como contexto de la biología general de la coagulación.
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Añadido a la biblioteca ASH: May 28, 2026 · Última actualización del sitio: 18 de junio de 2026