WP-77 Thermostable Anticoagulant (Whitmania pigra)
Thermostable (20–100 °C, pH 2–8) ~20.8 kDa anticoagulant protein from Whitmania pigra decoction — Zhang 2022 in vivo carrageenan thrombosis model.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Thermostable (20–100 °C, pH 2–8) ~20.8 kDa anticoagulant protein from Whitmania pigra decoction — Zhang 2022 in vivo carrageenan thrombosis model.
- Evidence level
- Preclinical (animal)
- Drug vs leech
- Purified natural compound
- Safety domains
- Bleeding
Clinical translation limit
WP-77's in vivo antithrombotic activity in mice does NOT establish clinical efficacy in humans. No FDA-approved derivative; W. pigra is a non-hematophagous TCM leech, not the FDA-cleared K040187 medicinal leech.
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Molecular weight
- 20,800 Da
- Source species
- Whitmania pigra
- Discovered
- 2022 · Zhang Y et al.
Biological Targets
- → aPTT pathway (intrinsic); thrombin time pathway
Key Citations
- Zhang Y et al. (2022), J Ethnopharmacol · PMID 35032585
External Resources
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