Lefaxin
Factor Xa inhibitor with anti-inflammatory properties.
Preclínico / mecanísticoLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Factor Xa inhibitor with anti-inflammatory properties.
- Evidence level
- In vitro
- Drug vs leech
- Purified natural compound
- Safety domains
- Bleeding
Clinical translation limit
Lefaxin's in vitro inhibition of Factor Xa does not establish clinical efficacy. No FDA-approved derivative exists. Mechanism is preclinical/biochemical only.
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Molecular weight
- 30,000 Da
- Source species
- Haementeria depressa
- Discovered
- 2003 · Faria et al.
Biological Targets
- → Factor Xa
- → Factor VII/tissue factor complex
Key Citations
- Faria F, Kelen EM, Sampaio CA, Bon C, Duval N, Chudzinski-Tavassi AM (1999), Thromb Haemost · PMID 10595640
External Resources
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