Therostasin
Factor Xa inhibitor from Theromyzon tessulatum — Kunitz-domain analog with novel selectivity profile.
Preclínico / mecanísticoLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Factor Xa inhibitor from Theromyzon tessulatum — Kunitz-domain analog with novel selectivity profile.
- Evidence level
- In vitro
- Drug vs leech
- Purified natural compound
- Safety domains
- Bleeding
Clinical translation limit
Therostasin's in vitro inhibition of Factor Xa does not establish clinical efficacy. No FDA-approved derivative exists. Mechanism is preclinical/biochemical only.
Molecular Profile
- Category
- Anticoagulant
- Evidence tier
- Preclinical
- Molecular weight
- 14,000 Da
- Source species
- Theromyzon tessulatum
- Discovered
- 1999 · Chopin V et al.
Biological Targets
- → Factor Xa
Key Citations
- Chopin V et al. (2000), J Biol Chem · PMID 10852926
External Resources
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