Leech VEGF Modulator
Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Purified natural compound
Clinical translation limit
Leech VEGF-pathway modulation is mechanistic/hypothetical and does NOT establish clinical angiogenic or wound-healing efficacy. No FDA-approved derivative exists; distinct from FDA-approved anti-VEGF (bevacizumab, ranibizumab) drugs, which are unrelated humanized monoclonal antibodies.
Molecular Profile
- Category
- Other
- Evidence tier
- Preclinical
- Molecular weight
- 45,000 Da
- Source species
- Hirudo medicinalis
Biological Targets
- → VEGF / VEGFR signaling axis
External Resources
Related Other Compounds
Granulin (leech-derived)
Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.
Leech PDGF Modulator
Platelet-derived growth factor pathway modulator — implications for wound-healing.
Leech Granulin-A
Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).
Buccalin-Like Peptide
Putative neuroactive signaling peptide identified in leech salivary tissue — named by analogy to mollusc buccalin; function speculative.