Sociedad Americana de Hirudoterapia

Buccalin-Like Peptide

Putative neuroactive signaling peptide identified in leech salivary tissue — named by analogy to mollusc buccalin; function speculative.

Preclínico / mecanísticoLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Molecular weight of Buccalin-Like Peptide compared with other characterized leech-derived compoundsHementerin80 kDaHementin80 kDaHementin-Like Protein (HLP-1)80 kDaLeech Collagenase70 kDaHaemadipsa yanyuanensis Progr…70 kDaLeech Apyrase67 kDaCalin65 kDaHyaluronidase60 kDaAntithrombin III binding prot…58 kDaCollagenolytic Fibrinolysin55 kDaLeech Thrombospondin-Like Pro…50 kDaBuccalin-Like Peptide1 kDa
Molecular weight (kilodaltons) of Buccalin-Like Peptide (highlighted) alongside other characterized leech salivary compounds. Smaller proteins/peptides generally diffuse and act faster.

Mechanistic Evidence Box

Preclinical / mechanistic
Page type
Compound profile
Evidence type
Putative neuroactive signaling peptide identified in leech salivary tissue — named by analogy to mollusc buccalin; function speculative.
Evidence level
Mechanistic discussion
Drug vs leech
Purified natural compound

Clinical translation limit

This peptide is named by sequence analogy only; biological function in leech is not established. No FDA-approved derivative exists and no clinical efficacy is claimed.

Molecular Profile

Category
Other
Evidence tier
Preclinical
Molecular weight
1,000 Da
Source species
Hirudo medicinalis
Discovered
2018
Buccalin-Like Peptide molecular structure

Biological Targets

  • → neuropeptide signaling (mechanism under characterization)

External Resources

    Related Other Compounds

    Granulin (leech-derived)

    Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.

    Leech VEGF Modulator

    Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.

    Leech PDGF Modulator

    Platelet-derived growth factor pathway modulator — implications for wound-healing.

    Leech Granulin-A

    Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).

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