Sociedad Americana de Hirudoterapia

Leech Saposin-Like Peptide

Saposin-like lipid-binding peptide identified in leech salivary transcriptome — putative membrane-active component.

Preclínico / mecanísticoLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Molecular weight of Leech Saposin-Like Peptide compared with other characterized leech-derived compoundsHementerin80 kDaHementin80 kDaHementin-Like Protein (HLP-1)80 kDaLeech Collagenase70 kDaHaemadipsa yanyuanensis Progr…70 kDaLeech Apyrase67 kDaCalin65 kDaHyaluronidase60 kDaAntithrombin III binding prot…58 kDaCollagenolytic Fibrinolysin55 kDaLeech Thrombospondin-Like Pro…50 kDaLeech Saposin-Like Peptide8 kDa
Molecular weight (kilodaltons) of Leech Saposin-Like Peptide (highlighted) alongside other characterized leech salivary compounds. Smaller proteins/peptides generally diffuse and act faster.

Mechanistic Evidence Box

Preclinical / mechanistic
Page type
Compound profile
Evidence type
Saposin-like lipid-binding peptide identified in leech salivary transcriptome — putative membrane-active component.
Evidence level
Mechanistic discussion
Drug vs leech
Purified natural compound

Clinical translation limit

This peptide is identified at sequence level only. Hypothesized membrane-active function is NOT biochemically verified. No FDA-approved derivative exists.

Molecular Profile

Category
Other
Evidence tier
Preclinical
Molecular weight
8,000 Da
Source species
Hirudo medicinalis
Discovered
2018
Leech Saposin-Like Peptide molecular structure

Biological Targets

  • → lipid membranes (mechanism under characterization)

External Resources

    Related Other Compounds

    Granulin (leech-derived)

    Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.

    Leech VEGF Modulator

    Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.

    Leech PDGF Modulator

    Platelet-derived growth factor pathway modulator — implications for wound-healing.

    Leech Granulin-A

    Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).

    ← Back to Compound Reference

    Este sitio web proporciona información educativa y no constituye consejo médico, diagnóstico ni recomendaciones de tratamiento. La terapia con sanguijuelas medicinales conlleva riesgos clínicamente significativos y debe ser realizada únicamente por profesionales calificados bajo protocolos aprobados institucionalmente. La autorización 510(k) de la FDA para sanguijuelas medicinales se limita a indicaciones específicas; las discusiones sobre uso investigativo y fuera de indicación se señalan correspondientemente. Para orientación médica específica, consulte a un profesional de salud calificado.