H. medicinalis Saliva Mass-Spectrometry Re-Characterization (2024)
2024 reproteomic re-characterisation of medicinal-leech saliva extending the Babenko 2020 proteome — Polishchuk 2024.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- 2024 reproteomic re-characterisation of medicinal-leech saliva extending the Babenko 2020 proteome — Polishchuk 2024.
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Leech-derived crude extract
Clinical translation limit
Descriptive proteomic inventory does NOT establish clinical efficacy. Individual factors require independent functional + clinical characterization. The K040187 device clearance covers whole-leech device use, not isolated proteins.
Molecular Profile
- Category
- Other
- Evidence tier
- Preclinical
- Source species
- Hirudo medicinalis
- Discovered
- 2024 · Polishchuk SN et al.
Biological Targets
- → composite secreted-saliva proteome catalogue (multi-target)
Key Citations
- Ayhan H et al. (2024), Immunol Res · PMID 39671012
External Resources
Related Other Compounds
Granulin (leech-derived)
Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.
Leech VEGF Modulator
Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.
Leech PDGF Modulator
Platelet-derived growth factor pathway modulator — implications for wound-healing.
Leech Granulin-A
Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).