H. nipponia Starvation-Induced Salivary Proteome
181 differentially expressed proteins (72 up / 109 down) in starved Hirudo nipponia salivary glands — Cai 2024 proteomic + transcriptomic profiling.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- 181 differentially expressed proteins (72 up / 109 down) in starved Hirudo nipponia salivary glands — Cai 2024 proteomic + transcriptomic profiling.
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Leech-derived crude extract
Clinical translation limit
The starvation-induced DEPs catalogue is a descriptive proteomic resource. No individual factor has been functionally characterized in this study; clinical translation requires per-protein characterization and human trials.
Molecular Profile
- Category
- Other
- Evidence tier
- Preclinical
- Source species
- Hirudo nipponia
- Discovered
- 2024 · Cai M et al.
Biological Targets
- → starvation-stress response in salivary gland tissue
Key Citations
- Cai M et al. (2024), PLoS One · PMID 38923974
External Resources
Related Other Compounds
Granulin (leech-derived)
Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.
Leech VEGF Modulator
Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.
Leech PDGF Modulator
Platelet-derived growth factor pathway modulator — implications for wound-healing.
Leech Granulin-A
Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).