Haemadipsa yanyuanensis Progranulin (Hy-PGRN)
Putative progranulin gene with 122 cysteine residues and nine tandem repeats — distinctive structural organization (Lin 2025 chromosome-level genome).
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Putative progranulin gene with 122 cysteine residues and nine tandem repeats — distinctive structural organization (Lin 2025 chromosome-level genome).
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Purified natural compound
Clinical translation limit
Hy-PGRN is identified at the genomic / sequence level only. Hypothesized roles based on mammalian progranulin homology are NOT clinically validated. No FDA-approved derivative exists.
Molecular Profile
- Category
- Anti-inflammatory
- Evidence tier
- Preclinical
- Molecular weight
- 70,000 Da
- Source species
- Haemadipsa yanyuanensis
- Discovered
- 2025 · Lin Y et al.
Biological Targets
- → unknown (homology-based, predicted role in wound microenvironment)
Key Citations
- Lin Y et al. (2025), BMC Genomics · PMID 41469844
External Resources
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