Chemical and mechanical alternatives to leech therapy: a systematic review and critical appraisal
Azzopardi EA, Whitaker IS, Rozen WM, Naderi N, Kon M (2011) · Journal of Reconstructive Microsurgery · n=25
Характеристика исследования
- Дизайн
- systematic review and critical appraisal of chemical and mechanical alternatives to medicinal leech therapy for venous congestion (Welsh Centre for Burns and Plastic Surgery, UK)
- Размер выборки (n)
- 25
- Вмешательство
- Synthesis of 25 published studies on devices and pharmacologic alternatives intended to replicate leech therapy effects (suction devices, chemical anticoagulant scarification protocols, etc.)
- Компаратор
- Implicit comparison to whole-leech therapy across heterogeneous study designs
- Первичная конечная точка
- Hierarchy-of-evidence grading of chemical and mechanical leech alternatives for venous congestion
- Основной результат
- Of 25 articles content-appraised, 12 were methodologically and statistically robust; heterogeneity precluded meta-analysis; Grade B level evidence that current device prototypes show proof-of-concept by providing suction and chemical anticoagulation following a surgically created wound
- Длительность наблюдения
- varied across included studies
- PMID
- 21780018
Ключевые выводы
- First systematic review of mechanical/chemical alternatives to whole-leech therapy for venous congestion
- 12 of 25 studies methodologically robust enough for critical appraisal
- Grade B evidence that device prototypes can provide proof-of-concept suction and chemical anticoagulation
- Heterogeneity in study design and outcomes precluded formal meta-analysis
- Important context for the question of whether mechanical scarification or device-based alternatives can replace whole-leech therapy in microsurgery
Ограничения
- Only 10-year search window (limits historical context)
- Hierarchy-of-evidence grading varies across included studies
- No quantitative synthesis - narrative review only
- Limited coverage of non-Western devices (e.g. Russian/Chinese designs)
- No formal cost-effectiveness comparison across alternatives
Клиническое значение
Azzopardi 2011 is the principal evidence summary on whether non-leech alternatives can replicate the venous-decongestion effects of whole-leech therapy. The Grade B conclusion is that mechanical/chemical alternatives have proof-of-concept but have not yet demonstrated equivalence to live-leech application. For ASH stakeholders and US microsurgery practitioners, this review supports the continued role of whole-leech therapy as the reference standard for venous-congestion salvage, while encouraging engagement with the device-development literature. The review also informs the Pannucci 2014 and Mozafari 2010 caution that whole-leech therapy is not universally superior to all alternatives.
Связанные исследования
Medicinal leech therapy in venous congestion of microsurgical flaps: a randomized comparison with heparin pinprick scarification
Merlino G, Carbone S, Servillo G, Marletta DA (2020)
Adjunctive medicinal leech therapy for venous congestion in free flaps: a German multicenter randomized trial
Lehnhardt M, Daigeler A, Behr B, Schmidt SV, Wallner C (2021)
Medicinal leeches and the microsurgeon: a four-year study, clinical series and risk benefit review
Whitaker IS, Josty IC, Hawkins S, Azzopardi E, Naderi N, Graf J, Damaris L, Lineaweaver WC, Kon M (2011)
Medicinal leeches for surgically uncorrectable venous congestion after free flap breast reconstruction
Pannucci CJ, Nelson JA, Chung CU, Fischer JP, Kanchwala SK, Kovach SJ, Serletti JM, Wu LC (2014)