Rosacea (Papulopustular Subtype)

Краткая информация для пациента

Есть ли FDA-допуск для этого показания?

Not FDA-cleared for rosacea. FDA cleared medicinal leeches only for venous congestion in microsurgical reconstruction (K040187, June 2004). Use for papulopustular rosacea is investigational.

Какие доказательства существуют?

Tier C (investigational). One small case series (Wollina 2018 n=18) reports Investigator Global Assessment improvement of 1-2 grades at 12 weeks; there are no randomized controlled trials. Evidence-based therapy per AAD and 2017 ROSCO consensus: topical metronidazole, ivermectin, azelaic acid, or oral doxycycline (sub-antimicrobial 40 mg modified-release). Brimonidine for persistent erythema. Pulsed dye laser or IPL for telangiectasias.

Основные риски

• Bleeding from bite sites for 6 to 24 hours after detachment
• Worsening of facial erythema or flushing in the short term
• Post-inflammatory hyperpigmentation, especially in darker Fitzpatrick skin
• Local skin infection or, rarely, Aeromonas infection
• Allergic reaction to leech saliva (uncommon)
• Permanent small scars at bite sites on the face
• Trigger of ocular rosacea if leech placed near eyelids
• Delay of evidence-based topical or oral therapy

Кому не следует это рассматривать

• Patients with ocular rosacea (specialty management required)
• Patients with phymatous rosacea (laser ablation or surgical management)
• Patients with rosacea fulminans (oral isotretinoin or systemic steroid)
• Patients on anticoagulants, with hemophilia, or with severe anemia
• Patients with darker Fitzpatrick skin types at high PIH risk
• Pregnant patients
• Patients who have not been offered topical metronidazole, ivermectin, or oral doxycycline

О чём спросить врача

• Have I tried topical metronidazole, ivermectin, or azelaic acid for at least 12 weeks?
• Am I a candidate for sub-antimicrobial doxycycline 40 mg modified-release?
• Should I see an ophthalmologist for ocular rosacea symptoms?
• Will leech placement risk worsening my flushing or burning?
• What is the practitioner's experience with facial leech placement and PIH prevention?
• Are leeches from an FDA-registered supplier and used only once?
• What is the cost and is it covered by insurance? (typically not covered)

Когда срочно обратиться за медицинской помощью

• Severe sudden facial swelling with fever (rosacea fulminans — emergency)
• New eye pain, blurred vision, or red painful eye (ocular rosacea)
• Spreading redness, warmth, pus, or red streaks on the face (cellulitis)
• Bleeding from a bite site lasting more than 24 hours
• Fever above 38.0 C / 100.4 F or chills
• Hives, facial or tongue swelling, throat tightness, or breathing difficulty