Effects of 17-E2 on growth and gonad development of overwintering Whitmania pigra
Research article published in Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2019)
Abstract
The present study was conducted to explores the effects of short-term addition of 17β-E2 on the growth,gonad development and internal quality of overwintering Whitmania pigra. Before overwintering,0. 0,1. 0,10. 0,25. 0,50. 0,100. 0 μg·L~(-1) of 17β-E2 were added to the aquaculture water for 6 weeks and then hibernated for 60 days. The changes of growth performance,gonad index,morphological structure of spermary( ovary),endogenous steroid hormones level and internal quality were measured. The results showed that the body weight,weight gain rate,specific growth rate,female gonad index,oocyte development and endogenous estrogen level of the leech increased first and then decreased with the increase of the concentration of exogenous 17β-E2,which were higher than those of the control group. The body weight,weight gain rate and specific growth rate of the leech at the concentration of 25 μg·L~(-1)17β-E2 were significantly higher than those of the other groups( P<0. 05),oocyte development and endogenous estrogen levels were significantly higher than those of other groups at the concentration of 50 μg·L~(-1)( P<0. 05). When the concentration of exogenous 17β-E2 was higher than 50 μg·L~(-1),the levels of male gonad index,spermatocyte development,endogenous androgen and progesterone were significantly inhibited( P< 0. 05). There was no significant difference in endogenous corticosteroid levels among the groups. In conclusion,short-term addition of exogenous 17β-E2 of 10-25 μg·L~(-1) could promote the growth of overwintering leeches,oocyte development and antithrombin activity without inhibiting the development of male gonads.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Resumen
The present study was conducted to explores the effects of short-term addition of 17-E2 on the growth,gonad development and internal quality of overwintering Whitmania pigra.
Por qué esto importa para la hirudoterapia
Este estudio investigó cómo la adición a corto plazo de 17β-estradiol afecta el crecimiento, el desarrollo gonadal y la calidad interna de las sanguijuelas Whitmania pigra que pasan el invierno antes de la hibernación. Los hallazgos son relevantes para la acuicultura de sanguijuelas y el ámbito de ASH al demostrar que concentraciones bajas específicas de 17β-E2 exógeno pueden promover el crecimiento de las sanguijuelas, potenciar el desarrollo ovocitario y aumentar la actividad antitrombina sin inhibir el desarrollo gonadal masculino. Esto sugiere posibles intervenciones hormonales para optimizar la cría y la calidad medicinal de las sanguijuelas. Sin embargo, la investigación es estrictamente un estudio aplicado de manejo ganadero, sin datos sobre hirudoterapia clínica ni sobre el uso terapéutico del secretoma de la sanguijuela en pacientes.
Citación
Effects of 17-E2 on growth and gonad development of overwintering Whitmania pigra
Wang S et al. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
Contexto clínico relacionado
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Añadido a la biblioteca ASH: May 27, 2026 · Última actualización del sitio: 18 de junio de 2026