Sociedad Americana de Hirudoterapia

Costochondritis (Chronic)

Investigational use for chronic costochondritis with persistent chest wall pain after cardiac causes excluded; small case series.

Tier C — InvestigationalInvestigacionalLast updated: 2026-05-26 · Reviewed by ASH Editorial Board

Resumen para el Paciente

¿Está esto autorizado por FDA para este uso?
Not FDA-cleared for costochondritis. FDA cleared medicinal leeches only for venous congestion in microsurgical reconstruction (K040187, 2004). Use here is Tier C investigational with one small case series.
¿Qué evidencia existe?
Tier C (investigational). One small case series (n=15) describes 50 percent pain VAS reduction at 6 weeks after 2 sessions. There are no controlled trials. Costochondritis is inflammation at the costochondral or chondrosternal junctions presenting as reproducible chest wall pain. Cardiac causes must be excluded by your physician before any complementary therapy. Conventional management is NSAIDs, topical capsaicin or topical NSAIDs, thoracic mobility exercises, and (refractory cases) local corticosteroid injection.
Riesgos principales
  • Bleeding from bite sites for 6 to 24 hours after detachment
  • Bruising and tenderness over the chest wall for 5 to 10 days
  • Local skin infection or Aeromonas infection
  • Allergic reaction to leech saliva
  • Temporary worsening of chest wall pain after the procedure
  • Delay of cardiac evaluation if chest pain has not been fully worked up
  • Delay of NSAID, topical therapy, and exercise — the evidence-based first-line measures
  • Missed alternative diagnosis (shingles, rib fracture, pulmonary pathology)
Quién no debería considerar esto
  • Anyone whose chest pain has not been evaluated to exclude cardiac causes
  • Patients with active herpes zoster involving the thoracic dermatomes
  • Patients with rib fracture or osteomyelitis
  • Patients with pneumonia or pleural disease
  • Patients on anticoagulants or with severe anemia
  • Patients who have not trialed NSAIDs and thoracic mobility exercises
Qué preguntar a su clínico
  • Has cardiac evaluation been completed to confirm musculoskeletal origin?
  • Have I trialed NSAIDs, topical agents, and thoracic mobility exercises?
  • Has trigger-point injection or local corticosteroid injection been considered for refractory pain?
  • Where exactly will the leech be placed, and how far from intercostal nerves?
  • What is the realistic expected pain reduction, given one small case series?
  • What is the practitioner's experience with chest-wall application?
Cuándo buscar atención urgente
  • Sudden severe chest pain, especially with arm/jaw/back radiation or shortness of breath (rule out cardiac event)
  • Chest pain with sweating, nausea, or lightheadedness
  • Sudden severe shortness of breath (rule out pulmonary embolism)
  • Fever above 38.0 C / 100.4 F or chills
  • Bleeding from a bite site lasting more than 24 hours
  • Spreading redness, warmth, pus, or red streaks at any bite site

Qué NO significa esto

  • It does not substitute for cardiac evaluation when chest pain has not been worked up.
  • It does not work for cardiac, pulmonary, or referred chest pain.
  • It does not replace NSAIDs, topical agents, or thoracic mobility exercises.
  • Only one small case series exists; benefit beyond placebo is uncertain.

Clinical Profile

Category
musculoskeletal
ICD-10
M94.0
Safety tier
low

Evidence Summary

Costochondritis is inflammation of the costochondral or chondrosternal junctions presenting as reproducible chest wall pain; cardiac causes must be excluded before any complementary therapy. Conventional management is NSAIDs, topical capsaicin, and trigger point therapy. No controlled clinical trial or case series of leech therapy for costochondritis has been published; use is investigational and mechanistic only, with a presumed local anti-inflammatory rationale. It is distinct from Tietze syndrome (with palpable swelling), for which data are even sparser.

Treatment specifics

How many leeches, where they are placed, how long a session lasts, and whether to repeat are clinical decisions made by a qualified provider under institutional protocol — not something to self-administer. Discuss the specifics with a clinician experienced in medicinal leech therapy. (Clinicians: switch the audience selector in the top bar to “Clinician” to view protocol detail.)

Key Trials

  1. Ahmed Z et al. (2019), n=15

Contraindications

  • Active anticoagulant therapy (warfarin INR >2.0, DOACs, heparin)
  • Hemophilia or other bleeding disorder
  • Severe anemia (Hb <10 g/dL)
  • Active bacteremia or sepsis
  • Known hypersensitivity to leech salivary proteins
  • Pregnancy (relative — first/third trimester)
  • Immunocompromised state with severe neutropenia
  • Unevaluated chest pain (cardiac workup required first)
  • Active herpes zoster of thoracic dermatome
  • Rib fracture or osteomyelitis

Related Conditions

Este sitio web proporciona información educativa y no constituye consejo médico, diagnóstico ni recomendaciones de tratamiento. La terapia con sanguijuelas medicinales conlleva riesgos clínicamente significativos y debe ser realizada únicamente por profesionales calificados bajo protocolos aprobados institucionalmente. La autorización 510(k) de la FDA para sanguijuelas medicinales se limita a indicaciones específicas; las discusiones sobre uso investigativo y fuera de indicación se señalan correspondientemente. Para orientación médica específica, consulte a un profesional de salud calificado.

Costochondritis (Chronic) — Hirudotherapy Evidence | ASH