Leech Saposin-Like Peptide
Saposin-like lipid-binding peptide identified in leech salivary transcriptome — putative membrane-active component.
Praeklinisch / mechanistischLast updated: 2026-05-26 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Saposin-like lipid-binding peptide identified in leech salivary transcriptome — putative membrane-active component.
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Purified natural compound
Clinical translation limit
This peptide is identified at sequence level only. Hypothesized membrane-active function is NOT biochemically verified. No FDA-approved derivative exists.
Molecular Profile
- Category
- Other
- Evidence tier
- Preclinical
- Molecular weight
- 8,000 Da
- Source species
- Hirudo medicinalis
- Discovered
- 2018
Biological Targets
- → lipid membranes (mechanism under characterization)
External Resources
Related Other Compounds
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Leech VEGF Modulator
Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.
Leech PDGF Modulator
Platelet-derived growth factor pathway modulator — implications for wound-healing.
Leech Granulin-A
Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).