Granulin (leech-derived)
Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.
- Evidence level
- Preclinical (animal)
- Drug vs leech
- Purified natural compound
Clinical translation limit
Leech-derived granulin's reported wound-healing and angiogenic activity in preclinical models does NOT establish clinical efficacy. No FDA-approved derivative exists. Distinct from human progranulin-targeted therapeutics in development for unrelated indications.
Molecular Profile
- Category
- Other
- Evidence tier
- Preclinical
- Molecular weight
- 13,000 Da
- Source species
- Hirudo medicinalis
Biological Targets
- → progranulin pathway, wound-healing
Key Citations
- Hong S et al. (1999), Eur J Biochem
External Resources
Related Other Compounds
Leech VEGF Modulator
Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.
Leech PDGF Modulator
Platelet-derived growth factor pathway modulator — implications for wound-healing.
Leech Granulin-A
Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).
Buccalin-Like Peptide
Putative neuroactive signaling peptide identified in leech salivary tissue — named by analogy to mollusc buccalin; function speculative.