Hman1 (Hirudinaria manillensis Macin)
Conserved cysteine-stabilized αβ macin from the Asian buffalo leech — Yu 2025 demonstrates retained antimicrobial function while Hman2/Hman3 paralogs degenerate.
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Conserved cysteine-stabilized αβ macin from the Asian buffalo leech — Yu 2025 demonstrates retained antimicrobial function while Hman2/Hman3 paralogs degenerate.
- Evidence level
- In vitro
- Drug vs leech
- Purified natural compound
- Safety domains
- Antibiotic stewardship
Clinical translation limit
Hman1's predicted antimicrobial activity is inferred from sequence conservation and expression patterns. No FDA-approved derivative; H. manillensis is not on the FDA K040187 cleared device species list.
Molecular Profile
- Category
- Antimicrobial
- Evidence tier
- Preclinical
- Source species
- Hirudinaria manillensis
- Discovered
- 2025 · Yu Y et al.
Biological Targets
- → bacterial membrane (broad-spectrum, gram-positive / gram-negative)
Key Citations
- Yu Y et al. (2025), Biology (Basel) · PMID 40427706
External Resources
Related Antimicrobial Compounds
Theromacin
Antimicrobial peptide active against Gram-negative bacteria — innate immunity of leech.
Theromyzin
Antimicrobial peptide; structural analogue of mammalian defensin family.
Macrostomin
Antimicrobial peptide active against Gram-positive bacteria — amphipathic alpha-helix.
Hirunipins
Newly-characterized antimicrobial peptide family (Kumar 2025) — candidate next-generation antibiotics against AMR pathogens.