LHyal (Leech Hyaluronidase)

Hyperactive Hirudo medicinalis hyaluronate hydrolase used for HA oligosaccharide industrial production — Liao 2023 yeast-surface-display recombinant biocatalyst.

Доклинические / механистические данныеLast updated: 2026-05-27 · Reviewed by ASH Editorial Board

Molecular weight (kilodaltons) of LHyal (Leech Hyaluronidase) (highlighted) alongside other characterized leech salivary compounds. Smaller proteins/peptides generally diffuse and act faster.

Mechanistic Evidence Box

Preclinical / mechanistic

Page type: Compound profile
Evidence type: Hyperactive Hirudo medicinalis hyaluronate hydrolase used for HA oligosaccharide industrial production — Liao 2023 yeast-surface-display recombinant biocatalyst.
Evidence level: In vitro
Drug vs leech: Recombinant (genetically expressed)

Clinical translation limit

LHyal's enzymatic activity in industrial HA oligosaccharide production does NOT establish clinical efficacy as a therapeutic agent. No FDA-approved LHyal derivative exists.

Molecular Profile

Category: ECM Enzyme
Evidence tier: Preclinical
Molecular weight: 50,000 Da
Source species: Hirudo medicinalis
Discovered: 2023 · Liao L et al.

LHyal (Leech Hyaluronidase) molecular structure

Biological Targets

→ hyaluronic acid (extracellular matrix); produces size-specific HA oligosaccharides

Key Citations

Liao L et al. (2023), Eng Microbiol · PMID 39628912

External Resources

Related ECM Enzyme Compounds

Hyaluronidase

Enzyme that degrades hyaluronic acid in extracellular matrix — 'spreading factor' enhancing diffusion of other SGS compounds.

Leech Collagenase

ECM-degrading enzyme — facilitates spread of salivary compounds at the bite site.

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