Leech Substance P Modulator

Salivary factor reported to modulate the substance P / neurokinin-1 nociceptive pathway.

Preclínico / mecanísticoLast updated: 2026-05-26 · Reviewed by ASH Editorial Board

Molecular weight (kilodaltons) of Leech Substance P Modulator (highlighted) alongside other characterized leech salivary compounds. Smaller proteins/peptides generally diffuse and act faster.

Mechanistic Evidence Box

Preclinical / mechanistic

Page type: Compound profile
Evidence type: Salivary factor reported to modulate the substance P / neurokinin-1 nociceptive pathway.
Evidence level: Mechanistic discussion
Drug vs leech: Purified natural compound

Clinical translation limit

Leech substance P modulator is documented mechanistically only; no human evidence. Hypothesized nociceptive modulation does NOT establish clinical analgesic efficacy, and no FDA-approved derivative exists.

Molecular Profile

Category: Analgesic
Evidence tier: Preclinical
Molecular weight: 14,000 Da
Source species: Hirudo medicinalis
Discovered: 2018

Leech Substance P Modulator molecular structure

Biological Targets

→ substance P signaling
→ neurokinin-1 receptor pathway

Key Citations

Liu Z et al. (2019), Parasit Vectors

External Resources

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