Antithrombotic Therapy in Patients with Complex Percutaneous Coronary Intervention and Cardiogenic Shock
Review published in Interv Cardiol Clin (2024)
Abstract
Managing antithrombotic therapy in patients undergoing complex and high-risk in indicated patients, including those treated with complex percutaneous coronary intervention (PCI) or presenting with cardiogenic shock (CS), is challenging. This review highlights the critical role of antithrombotic therapy, during and after PCI, to optimize the efficacy while minimizing risks. Unfractionated heparin remains the mainstay anticoagulant for complex PCI and CS, with bivalirudin as a potential safer alternative. Cangrelor offers consistent antiplatelet effects, especially when timely absorption of oral agents is uncertain.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Summary
This review highlights antithrombotic therapy in complex percutaneous coronary intervention or cardiogenic shock, noting that unfractionated heparin remains the mainstay anticoagulant, bivalirudin is a potential safer alternative, and cangrelor gives consistent antiplatelet effect when oral-agent absorption is uncertain.
Why This Matters for Hirudotherapy
This review examines antithrombotic therapy management during and after complex percutaneous coronary intervention (PCI) and in cardiogenic shock, noting that unfractionated heparin remains the mainstay anticoagulant while bivalirudin is discussed as a potentially safer alternative. The abstract does not mention leeches, hirudin, the leech secretome, or any leech-derived intervention. The focus is entirely on pharmacological antithrombotic strategies in interventional cardiology. Bivalirudin (formerly Hirulog) is a synthetic peptide anticoagulant designed partly on the C-terminal sequence of hirudin, the anticoagulant of the medicinal leech (Maraganore et al., 1990); this paper studies the drug, not leech therapy.
Citation
Reference (Vancouver style)
Larrubia Valle JI, Urbano-Carrillo CA, Costa F. Antithrombotic Therapy in Patients with Complex Percutaneous Coronary Intervention and Cardiogenic Shock. Interv Cardiol Clin. 2024;13(4):517-525. doi:10.1016/j.iccl.2024.06.006. PMID: 39245551
Bibliographic details (authors, volume, pages, DOI) are taken from the PubMed record.
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