Tissue factor pathway inhibitor in atherosclerosis

Tissue factor pathway inhibitor (TFPI) reduces the development of atherosclerosis by regulating tissue factor (TF) mediated coagulation pathway. In this review, we focus on recent findings on the inhibitory effects of TFPI on endothelial cell activation, vascular smooth muscle cell (VSMC) proliferation and migration, inflammatory cell recruitment and extracellular matrix which are associated with the development of atherosclerosis. Meanwhile, we are also concerned about the impact of TFPI levels and genetic polymorphisms on clinical atherogenesis. This article aims to explain the mechanism in inhibiting the development of atherosclerosis and clinical effects of TFPI, and provide new ideas for the clinical researches and mechanism studies of atherothrombosis.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

This review focuses on tissue factor pathway inhibitor (TFPI) effects on endothelial activation, smooth muscle proliferation and migration, inflammatory cell recruitment and extracellular matrix in atherosclerosis, and discusses TFPI levels and genetic polymorphisms in clinical atherogenesis.

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