American Society of Hirudotherapy

Bloodletting as medical therapy for 2500 years

Research article published in Tidsskrift for den Norske laegeforening (1999)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Research reportDrug DevelopmentUlvik RJ et al. · Tidsskrift for den Norske laegeforening, 1999

Abstract

Bloodletting has been part of the history of medicine for more than 2500 years. Up to the end of the Middle Ages, the rationale for bloodletting originated from the ancient greek humoral theory. The great scientific progress from the 16th century and onward, apparently did not weaken its position. Prominent physicians such as Andreas Vesalius (1514-64), William Harvey (1578-1657) and Thomas Sydenham (1624-89) defended bloodletting. In the beginning of the 19th century the use of leeches became the major technique of bloodletting in Europe. In Norway bloodletting was mentioned in royal decrees from the 13th century, and the method became popular in folk medicine. At the end of the 19th century bloodletting came at last to be regarded as ineffective for most of its traditional purposes, and its use declined rapidly. Today, however, bloodletting is being restored in modern medicine as the most effective method of treating the increasing frequent disorders caused by iron overload.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeEnglish AbstractHistorical ArticleJournal Article
Indexed MeSH termsBloodlettingEuropeGreeceHistory, 16th CenturyHistory, 17th CenturyHistory, 18th CenturyHistory, 19th CenturyHistory, 20th CenturyHistory, AncientHistory, MedievalHumansNorway

Summary

Bloodletting as medical therapy for 2500 years.

Why This Matters for Hirudotherapy

This historical article reviews the 2,500-year medical history of bloodletting from ancient Greek humoral theory through the 19th century, noting that the use of leeches became the major bloodletting technique in Europe during that period. The article describes the rapid decline of bloodletting at the end of the 19th century as it came to be regarded as ineffective for most traditional purposes, and states that bloodletting is being restored in modern medicine as the most effective method of treating disorders caused by iron overload. This provides historical context for the prominence and subsequent fall from favor of medicinal leeching, though the abstract provides no data on the leech secretome, modern hirudotherapy techniques, or clinical efficacy of leech therapy itself.

Citation

Bloodletting as medical therapy for 2500 years

Ulvik RJ et al. · Tidsskrift for den Norske laegeforening, 1999

Added to ASH library: May 27, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.