Smart Library

Investigational use with small case series suggesting frequency reduction in chronic tension headache via reduction of pericranial muscle tension and venous congestion.

Investigational use for symptomatic relief of grade II-III internal/external hemorrhoidal disease; does not address anatomic prolapse.

Investigational adjunctive use in primary open-angle glaucoma; weak case-series evidence. Not a substitute for IOP-lowering eye drops or surgery.

Investigational use for dry eye disease; mechanism via reduction of meibomian gland inflammation. Weak case-series evidence.

Investigational adjunctive use; one small pilot suggests transient improvement in tender-point and quality-of-life scores. Not a primary treatment.

Investigational use for chronic lipodermatosclerosis; small case series suggest softening of fibrotic gaiter-area skin changes.

Investigational use for androgenic alopecia; mechanism via local scalp perfusion improvement. Single-arm series only.

Investigational use for erythematotelangiectatic rosacea; case-series evidence for reduction in facial erythema.

Investigational use for localized stable plaque psoriasis; small case series suggest plaque thinning. Not a primary treatment.

Investigational use for localized refractory atopic dermatitis; very limited case-series evidence.

Investigational use for chronic recurrent (non-acute) cellulitis with underlying lymphedema or venous insufficiency.

Investigational adjunctive use; case-series evidence for limb-volume reduction when combined with complete decongestive therapy.

Investigational use for acute monoarticular gout when NSAIDs and colchicine are contraindicated; small case series.

Investigational use for chronic mid-substance Achilles tendinopathy; case-series evidence for pain and VISA-A score improvement.

Investigational use for non-surgical rotator cuff tendinopathy and chronic shoulder impingement; case-series evidence for pain reduction.

Investigational use for stenosing tenosynovitis of the digital flexor pulleys; small case series.

Investigational use for early-stage Dupuytren's nodules; case-series evidence for nodule softening, not for established contracture.

Investigational use for plantar fascia nodules in early Ledderhose disease; case-series evidence for symptomatic improvement.

Investigational use for category III CP/CPPS; small case series suggest symptom reduction. Multimodal therapy remains standard.

Investigational adjunctive use for chronic endometriosis-related pelvic pain; very limited evidence. Not a substitute for hormonal or surgical management.

Investigational use for primary dysmenorrhea refractory to NSAIDs and hormonal contraception; small case series.

Investigational use for non-specific chronic pelvic pain syndrome; case-series evidence for symptom reduction within multimodal management.

Investigational use for chronic subjective tinnitus; case-series evidence for THI score improvement. Mechanism speculative.

Investigational use for residual symptoms in the post-acute phase of DVT (>6 weeks); contraindicated in acute DVT.

Investigational adjunctive use for Hurley stage I-II hidradenitis suppurativa in quiescent phase between flares.

Investigational use for pulsatile vascular-origin tinnitus distinct from subjective tinnitus; case-report evidence only.

Investigational adjunct for vestibular attack frequency reduction in definite Meniere's disease per AAO-HNS 2015 criteria; case-series evidence.

Investigational adjunct in acute idiopathic facial nerve palsy; case-series suggest faster House-Brackmann recovery as add-on to corticosteroids.

Investigational use for classical trigeminal neuralgia refractory to first-line carbamazepine; anecdotal pain-frequency reduction.

Investigational use for lumbosacral radicular pain without disc herniation (foraminal stenosis, facet hypertrophy, lateral recess); case-series evidence.

Investigational adjunct in stage II frozen shoulder; small case series suggest accelerated range-of-motion recovery as add-on to physiotherapy.

Investigational use for insertional Achilles tendinopathy distinct from mid-substance disease; weaker case-series response.

Investigational use for stenosing tenosynovitis of the first dorsal extensor compartment; small case series.

Investigational use for trigger finger recurrent after corticosteroid injection failure; pre-surgical alternative explored in case series.

Investigational use for symptomatic plantar calcaneal spur; distinguished from plantar fasciitis by radiographic spur with localized pain.

Investigational use for chronic subacromial bursitis distinct from acute infectious bursitis; case-series evidence for pain reduction.

Investigational use for chronic greater trochanteric pain syndrome including bursitis and gluteal tendinopathy; case-series evidence.

Investigational use for chronic costochondritis with persistent chest wall pain after cardiac causes excluded; small case series.

Investigational use for SI joint mechanical pain with positive provocation tests; case-series evidence for pain reduction.

Investigational use for chronic coccyx pain after fall, childbirth, or idiopathic onset; small case series for refractory cases.

Investigational use for isolated piriformis syndrome with positive FAIR test and excluded lumbar pathology; case-series evidence.

Investigational adjunct for chronic migraine (≥15 days/month, ≥8 migrainous) refractory to two preventive classes; distinct from episodic migraine.

Investigational adjunct for chronic tension-type headache (≥15 days/month) with persistent pericranial muscle tenderness; small case series.

Investigational adjunct for cervicogenic headache referred from upper cervical (C1-C3) joints; case-series evidence for pain reduction.

Investigational adjunct for adult recalcitrant atopic dermatitis (EASI >21) refractory to dupilumab or JAK inhibitor; very preliminary data.

Investigational adjunct for chronic plaque psoriasis recalcitrant to biologic therapy; very preliminary case-series evidence.

Investigational adjunct for papulopustular rosacea subtype with persistent inflammatory lesions; small case series.

Investigational adjunct for Hurley stage I localized hidradenitis suppurativa; distinct from Hurley II-III with extensive disease.

Investigational adjunct for keloid scars refractory to intralesional corticosteroid; case series suggest volume reduction as adjunctive therapy.

Investigational adjunct for hypertrophic scars (within original wound boundary) distinct from keloid; case-series evidence for volume reduction.