Hirudotherapy Atlas

792 curated entries across 5 evidence registries — unified entry point for clinicians, researchers, and policy analysts navigating the entire ASH knowledge base.

Last Updated: May 27, 2026Reviewed by: Andrei Dokukin, MD

Conditions atlas \u2014 mixed Tier A/B/CReference index

→ Coverage map (tier view)→ Atlas by organ system (system view)

792

Total registry entries across all 5 atlases

Conditions Atlas

199

Medical indications where hirudotherapy has been applied — tier-classified, ICD-10 coded, evidence-graded.

Tier A

Tier B

186

Tier C

Compound Reference

201

Salivary proteins, FDA-derived drugs, and reference anticoagulants — molecular targets, PubChem CIDs, RCSB PDB structures.

Spanning hirudin (1884) → modern direct thrombin/Xa inhibitors

RCT Library

169

Randomized controlled trials — GRADE-rated certainty, PMID-linked, full Study Profile with n / intervention / endpoint.

13,419 total participants enrolled

Biographies

Historical and contemporary figures whose work shaped hirudotherapy from biochemistry to clinical surgery.

201 key publications · Hippocrates → contemporary

Jurisdictions

155

Global regulatory bodies governing medicinal leech therapy — device clearance, drug classification, traditional medicine frameworks.

31 device-cleared · 9 traditional medicine

Research Library

21+

Long-form research articles, narrative reviews, systematic reviews, case series, and methodology essays.

Complements the structured registries above

How the registries cross-link

Each condition page lists detailed RCT entries investigating it (when present in the RCT Library)
Each RCT page links back to its condition page via a header chip
Each biography page lists the compounds the researcher influenced (cross-references to /compound/[slug])
Each jurisdiction page links to related jurisdictions in the same region or harmonization bloc
The global sitemap exposes all entries to search engines for full crawlability

Editorial integrity

All entries in these registries undergo PubMed PMID verification before inclusion. The ASH editorial policy explicitly forbids:

Fabricated PMIDs or placeholder citations
Plausible-sounding but unverifiable trial entries
Specific regulation codes without verified source
Quotes attributed to historical figures without primary source

Where uncertainty exists (e.g., a regulator's specific leech-therapy stance), entries are honestly marked as "unregulated" with explicit notes — never inflated to a status we cannot defend.