American Society of Hirudotherapy

Non-Occlusive Mesenteric Ischemia Due to Hirudotherapy: A Case Report

Case report published in Cureus (2020)

Last Updated: March 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Clinical TrialsDrug DevelopmentSafety & Infection ControlAkalın Ç, Ekmen N · Cureus, 2020

Abstract

Leech therapy, which can lead to complications such as anemia and bleeding, has been used to treat many diseases since ancient times. Furthermore, some substances in leech saliva are known to have anticoagulant effects. Acute mesenteric ischemia, which develops due to mesenteric vascular obstruction, can be treated medically or surgically. Non-occlusive mesenteric ischemia (NOMI) occurs as a result of decreased blood flow in mesenteric vessels due to hypovolemia, hypotension, etc. In this report, we mentioned a 57-year-old male patient who was admitted to the emergency department with syncope and weakness. In his medical history, the patient was stated to have used leech therapy to treat diabetic wounds on his feet, and prolonged and unstoppable bleeding was seen after leech bites. On his physical examination, there was tenderness in all quadrants of the abdomen. Abdominal computed tomography without contrast agent showed hepatic portal venous gas and pneumatosis cystoides intestinalis (PSI). The patient underwent laparotomy owing to the development of acute abdomen during the follow-up. Necrosis was seen in the terminal ileum and entire colon. Low flow in mesenteric vascular vessels of these necrotic segments was indicated with intraoperative Doppler ultrasonography. All necrotic segments were resected and open end-ileostomy was performed. The patient was discharged on the 17th day of follow-up. In conclusion, excessive bleeding caused by leech therapy can cause NOMI.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeCase ReportsJournal Article

Summary

Leech therapy, which can lead to complications such as anemia and bleeding, has been used to treat many diseases since ancient times. Furthermore, some substances in leech saliva are known to have anticoagulant effects.

Why This Matters for Hirudotherapy

Contributes clinical evidence for the therapeutic application of leech therapy.

Citation

Non-Occlusive Mesenteric Ischemia Due to Hirudotherapy: A Case Report.

Akalın Ç, Ekmen N · Cureus, 2020

Added to ASH library: March 18, 2026 · Site last updated: March 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.

Non-Occlusive Mesenteric Ischemia Due to Hirudotherapy: A Case Report | ASH