American Society of Hirudotherapy

Medicinal leech therapy in pain syndromes: a narrative review

Case report published in Wiener medizinische Wochenschrift (1946) (2014)

Last Updated: March 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Salivary PharmacologyClinical TrialsKoeppen D, Aurich M, Rampp T · Wiener medizinische Wochenschrift (1946), 2014

Abstract

Medicinal leech therapy is used in a variety of conditions; most of which have pain as a major symptom. Its mode of action relies on the injection of leech saliva into patients' tissues during the process of blood withdrawal. Leech saliva contains active ingredients with anti-inflammatory, thrombolytic, anti-coagulant and blood- and lymph-circulation enhancing properties. A specific analgesic substance within the leech saliva is yet to be identified. Pain relief from leech therapy is rapid, effective and long-lasting in many conditions. This review compiles studies and case reports that provide clinical evidence for leech therapy's analgesic effects.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal ArticleReview
Indexed MeSH termsAnimalsChronic PainEdemaHematomaHumansLeechesLeechingOsteoarthritisPalliative CareRandomized Controlled Trials as TopicSalivaTennis Elbow

Summary

Medicinal leech therapy is used in a variety of conditions; most of which have pain as a major symptom. Its mode of action relies on the injection of leech saliva into patients' tissues during the process of blood withdrawal.

Why This Matters for Hirudotherapy

Advances understanding of leech salivary bioactive compounds and their therapeutic potential.

Citation

Medicinal leech therapy in pain syndromes: a narrative review.

Koeppen D, Aurich M, Rampp T · Wiener medizinische Wochenschrift (1946), 2014

Added to ASH library: March 18, 2026 · Site last updated: March 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.

Medicinal leech therapy in pain syndromes: a narrative review | ASH