American Society of Hirudotherapy

Cutaneous pseudolymphoma: a case series of three patients

Case series published in Front Med (2025)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Case reportSafety & Infection ControlYao et al. · Frontiers in medicine, 2025

Abstract

Cutaneous pseudolymphoma is a type of reactive lymphoid hyperplasia that pathologically and/or clinically mimics cutaneous lymphoma. It has a variety of pathogenic factors. However, in many cases, no etiology can be identified. The histopathological findings of cutaneous pseudolymphoma can only be used as the basis for suspected diagnosis. Clinical data, further diagnostic tests and follow-up are needed to confirm the diagnosis. This article reports three cases of cutaneous pseudolymphoma, with different etiology, clinical manifestations and treatment methods. The purpose of this article is to emphasize that the etiology and clinical manifestations of cutaneous pseudolymphoma are diverse, and targeted treatment strategies and long-term follow-up are needed.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeCase ReportsJournal Article

Summary

Case series of three cutaneous-pseudolymphoma patients including hirudotherapy-associated context.

Why This Matters for Hirudotherapy

This case series examined three cases of cutaneous pseudolymphoma, a reactive lymphoid hyperplasia that mimics cutaneous lymphoma, to emphasize its diverse etiologies, clinical manifestations, and the necessity for targeted treatment strategies and long-term follow-up. While understanding various skin pathologies and reactive cutaneous conditions is broadly relevant to clinical practice, this article has no direct relevance to the American Society of Hirudotherapy. The study focuses entirely on diagnostic challenges and standard dermatological management. Furthermore, the provided abstract does not mention or evaluate the use of leeches, hirudotherapy, or the leech secretome at any point.

Citation

Cutaneous pseudolymphoma: a case series of three patients.

Yao et al. · Frontiers in medicine, 2025

Added to ASH library: May 27, 2026 · Site last updated: June 18, 2026

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