American Society of Hirudotherapy

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Leech Defensin

Defensin-family cationic antimicrobial peptide identified in leech salivary tissue.

Preclinical / mechanisticIn vitro

Leech Cecropin

Cecropin-homolog antimicrobial peptide identified in the leech salivary secretome.

Preclinical / mechanisticIn vitro

Leech Macin

Macin-family broad-spectrum antimicrobial protein identified in leech immune tissue and salivary secretome.

Preclinical / mechanisticIn vitro

Neuromacin

Macin-family antimicrobial protein with reported neuronal-tissue specificity — leech innate immunity component.

Preclinical / mechanisticIn vitro

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.

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