American Society of Hirudotherapy

Reconstruction of the soft tissue defects of foot and ankle with neural-island flaps: mono-institutional case series

Research article published in Journal of reconstructive microsurgery (2011)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Research reportClinical TrialsYu D et al. · Journal of reconstructive microsurgery, 2011

Abstract

The aim of this report is to show the results obtained from using the neural-island flap to cover the soft tissue defects of the foot and ankle. This is the first report of the neural-island flap series since the introduction of this flap to the literature in 2003. Between 2002 and 2009 "neural-island flap" was used to treat 20 patients of various lesions on the foot and ankle. All of the patients had serious soft tissue defects that compromised tendons, bones, or joints. In 16 patients, the tissue defects were completely and successfully covered with an uncomplicated postoperative course. In 4 patients the flaps presented venous congestion and intermittent bleeding and leech application was performed for 2 to 3 days postoperatively. Two of these flaps healed completely without any flap loss. In one patient because the partial flap necrosis occurred in distal one-fourth of the flap, skin grafting was performed after 1 week of vacuum-assisted closure application. Total flap necrosis occurred in only one patient who was suffering from Buerger disease. The authors conclude that the neural-island flap is a highly versatile, easy, and reproducible flap that avoids the use of complicated and risky reconstruction options. It can be considered as an alternative reconstruction option particularly in problematic cases that are not suitable for local or free tissue transfers.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal Article
Indexed MeSH termsAdultAgedAnimalsDiabetic FootFemaleFootGraft SurvivalHumansLeechingMaleMiddle AgedNecrosis

Summary

Reconstruction of the soft tissue defects of foot and ankle with neural-island flaps: mono-institutional case series.

Why This Matters for Hirudotherapy

This mono-institutional case series reports outcomes for the neural-island flap in covering soft tissue defects of the foot and ankle in 20 patients, 16 of whom had uncomplicated postoperative courses. In 4 patients who developed venous congestion with intermittent bleeding, leech application (leeching) was performed for 2 to 3 days postoperatively, and 2 of these flaps healed completely without loss. For ASH, this article is directly relevant: it documents medicinal leech therapy used as a salvage measure for venous congestion in surgical flaps. Caveat: the leeching detail is a secondary finding within a small, uncontrolled case series, and the report does not isolate or quantify leeching-specific outcomes.

Citation

Reconstruction of the soft tissue defects of foot and ankle with neural-island flaps: mono-institutional case series

Yu D et al. · Journal of reconstructive microsurgery, 2011

Added to ASH library: May 27, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.