American Society of Hirudotherapy

Vascular complications of vascularized composite tissue transfer: outcome and salvage techniques.

Research article published in Microsurgery (1993)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Research reportClinical TrialsDrug DevelopmentYajima et al. · Microsurgery, 1993

Abstract

Two hundred fifty-two vascularized composite tissue transfers were performed from 1985 to 1992 at Nara Medical University Hospital. Free tissue transfers were performed in 185 patients and island tissue transfers in 67 patients. Of these, 39 flaps were reexplored because of vascular complications. On initial reexploration, vascular obstruction was found at the site of anastomosis or in the main vascular pedicle in 36 patients and in the perforating vessels to the monitor flap in three patients. Arterial thrombus occurred in 11 patients, venous thrombosis in 12, and both in nine. Twenty-five reexplored flaps were salvaged. Initially, heparin was administered systemically when vascular compromise was suspected intraoperatively or postoperatively. Recently, we have used a "continuous local heparinization" technique to minimize blood loss. This method has been used in 12 patients who underwent reexploration and in nine patients in whom vascular compromise was suspected. Nineteen flaps survived completely, and two flaps failed.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal Article
Indexed MeSH termsAdolescentAdultAgedChildChild, PreschoolFemaleGraft Occlusion, VascularGraft SurvivalHeparinHumansMaleMiddle Aged

Summary

Two hundred fifty-two vascularized composite tissue transfers were performed from 1985 to 1992 at Nara Medical University Hospital. Free tissue transfers were performed in 185 patients and island tissue transfers in 67 patients.

Why This Matters for Hirudotherapy

This study reviewed 252 vascularized composite tissue transfers performed from 1985 to 1992, documenting vascular complications in 39 reexplored flaps (arterial thrombus in 11, venous thrombosis in 12, both in 9) and salvage techniques including systemic heparin and a 'continuous local heparinization' method used in 21 patients. While leech therapy is sometimes employed in flap salvage for venous congestion, this study made no mention of leeches or hirudotherapy—salvage relied entirely on surgical reexploration and heparin administration. The relevance to ASH's domain is therefore negligible beyond the shared clinical context of managing post-surgical vascular thrombosis.

Citation

Vascular complications of vascularized composite tissue transfer: outcome and salvage techniques.

Yajima et al. · Microsurgery, 1993

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