American Society of Hirudotherapy

Venous Thromboembolism Prophylaxis in Foot and Ankle Surgery: A Worldwide Survey

Research article published in The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons (2024)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Research reportClinical TrialsZambelli et al. · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 2024

Abstract

Current recommendations on thromboprophylaxis for foot and ankle (FA) surgery are often inconsistent and generally based on weak evidence. The aim of this survey study was to evaluate the current practice among orthopedic surgeons regarding venous thromboembolism (VTE) prophylaxis following FA surgery. From February 2019 to March 2020, an online questionnaire was sent by e-mail to orthopedic societies across the world. The questionnaire was hosted by the International Society of Thrombosis and Haemostais RedCAP platform. Topics of interest were VTE rates following FA surgery, duration and type of thromboprophylaxis, bleeding complications, VTE risk factors for prophylaxis and use of risk assessment. A total of 693 FA orthopedic surgeons from all continents completed the survey of whom 392 (57%) performed more than 200 FA procedures per year. A total of 669/693 (97%) respondents stated that thromboprophylaxis is necessary in FA surgeries. When thromboprophylaxis was prescribed, half of surgeons prescribed it for the duration of immobilization. Acetylsalicylic acid, low molecular weight heparin and direct-oral anticoagulants were, in this order, the preferred choice. Acetylsalicylic acid and low molecular weight heparin were predominantly prescribed in North America and Europe, respectively. Previous deep vein thrombosis, immobility, obesity and inherited thrombophilia were considered the main risk factors indicative of thromboprophylaxis use. In this survey, most surgeons agree that thromboprophylaxis is indicated for FA surgery, but the prescription, type and duration of prophylaxis differs greatly with a large intercontinental discrepancy. These survey results could be a foundation for developing uniform guidelines to optimize thromboprophylactic strategies in FA procedures around the world.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal Article
Indexed MeSH termsHumansAnticoagulantsVenous ThromboembolismAnkleHeparin, Low-Molecular-WeightSurveys and QuestionnairesAspirinPostoperative Complications

Summary

Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.

Why This Matters for Hirudotherapy

This worldwide survey collected responses from 693 foot-and-ankle orthopedic surgeons and found that 97% (669/693) considered thromboprophylaxis necessary after foot and ankle surgery, yet the choice, type, and duration varied widely, with aspirin favored in North America and low-molecular-weight heparin in Europe, and the authors note current recommendations rest on generally weak evidence. Its relevance to hirudotherapy is peripheral, situating leech-related anticoagulation interest within the broader, unsettled landscape of perioperative thromboprophylaxis and antithrombotic decision-making. Honest caveat: this is a survey of stated practice and opinion, not an outcomes trial, and it does not mention leeches, hirudin, or any leech-derived agent; it should not be read as evidence about hirudotherapy.

Citation

Venous Thromboembolism Prophylaxis in Foot and Ankle Surgery: A Worldwide Survey.

Zambelli et al. · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 2024

Added to ASH library: May 28, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.