American Society of Hirudotherapy

Use of the medicinal leech for salvage of venous congested microvascular free flaps of the head and neck

Retrospective case series published in Am J Otolaryngol (2011)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Research reportClinical TrialsKoch CA, Olsen SM, Moore EJ · American journal of otolaryngology, 2011

Abstract

OBJECTIVE: The objective of the study was to determine the utility of leech therapy in venous congested microvascular free flaps in which venous outflow could not be established or surgical revision was unsuccessful. METHODS: We conducted a retrospective review of all patients at a tertiary referral center from January 2002 to December 2008 who received leech therapy for a venous congested microvascular free flap in which venous outflow could not be established primarily or failed surgical revision. RESULTS: Six patients were identified. Leech therapy was required for a median of 9 days (4-14 days). The median lowest hemoglobin level per patient was 8.0 g/dL (5.4-9.3 g/dL). All patients (6/6, 100%) required blood transfusions during therapy. The median number of units of packed red blood cells transfused per patient was 13.5 U (4-29 U). All flaps (6/6, 100%) were successfully salvaged with leech therapy. There was one minor complication, observed as 2 episodes of syncope in the same patient, related to anemia. There were no cases of infection transmitted as a result of leech therapy. CONCLUSIONS: Leech therapy can be used to successfully salvage venous congested microvascular free flaps in the absence of primary venous outflow. Leech therapy can be used safely and with little morbidity compared with other reports.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal Article
Indexed MeSH termsAdolescentAgedAnimalsBlood TransfusionCarcinoma, Squamous CellFemaleFree Tissue FlapsGraft SurvivalHead and Neck NeoplasmsHumansLeechingLip

Summary

Six patients with venous-congested microvascular head and neck free flaps treated with leech therapy: 100% flap salvage. All 6 required blood transfusion (median 13.5 units); no documented infection transmissions.

Why This Matters for Hirudotherapy

This retrospective review identified six patients who received leech therapy for venous congested microvascular free flaps in which venous outflow could not be established primarily or surgical revision failed; all six flaps were successfully salvaged, with leech therapy used for a median of 9 days. Every patient required blood transfusions (median 13.5 units of packed red blood cells; median lowest hemoglobin 8.0 g/dL), with one minor complication of syncope related to anemia and no infections transmitted by leech therapy. This is directly relevant to ASH and hirudotherapy practice because it documents real-world clinical outcomes of medicinal leech therapy for flap salvage, including both its effectiveness and its principal morbidity burden of transfusion-requiring blood loss. An honest caveat is that the very small sample (n=6) and retrospective single-center design limit generalizability, and there is no comparison group.

Citation

Use of the medicinal leech for salvage of venous congested microvascular free flaps of the head and neck.

Koch CA, Olsen SM, Moore EJ · American journal of otolaryngology, 2011

Added to ASH library: May 26, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.