American Society of Hirudotherapy

The timing of neovascularization in fingertip replantation by external bleeding

Research article published in Plastic and reconstructive surgery (2002)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Research reportClinical TrialsHan et al. · Plastic and reconstructive surgery, 2002

Abstract

To overcome venous congestion in fingertip replantation with no venous anastomosis, the authors have used a salvage procedure that consists of continuous external bleeding through a stab incision on the paraungual area and dripping a heparinized saline solution at the incision site to maintain external bleeding. Because this method requires continuous bleeding for a certain period of time, it may be a great burden on the patient; therefore, it is most important to minimize the duration of bleeding. Many authors have studied the timing of the new venous channel formation of the flap. However, to our knowledge, a study on fingertip replantations has not yet been performed. From June of 1985 to November of 1999, the authors performed fingertip replantations on 144 fingers of 137 patients using our salvage procedure at Korea University Guro Hospital. Among the 144 fingers, 101 fingers of 96 patients were successfully transplanted, including those with partial necrosis. The authors reviewed the medical records of these 101 fingers retrospectively; they compared and analyzed the necessary duration of external bleeding according to sex, age, level of injury, cause of amputation, and the type of injury. The average period of the salvage procedure was 7.6 days. Regarding age, the shortest period (5.5 days) was required for patients younger than 10 years. On the basis of the types of injuries, the duration of bleeding was shortest for the guillotine injury group (5.9 days) compared with crush (8.2 days) or avulsion (8.0 days) injuries. Sex and level of injury did not make much difference in the duration of the procedure.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal Article
Indexed MeSH termsAdolescentAdultAnticoagulantsChildFemaleFinger InjuriesFingersHeparinHumansMaleMiddle AgedNeovascularization, Physiologic

Summary

Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.

Why This Matters for Hirudotherapy

This retrospective review of 101 successful fingertip replantations (of 144 attempted) studied a salvage method for venous congestion in fingers lacking a venous anastomosis: continuous controlled external bleeding through a stab incision with heparinized saline, maintained until new venous outflow channels form. The average duration of the bleeding procedure was 7.6 days, shortest in children under 10 (5.5 days) and in guillotine injuries (5.9 days) versus crush (8.2) or avulsion (8.0) injuries. This is highly relevant to hirudotherapy because medicinal leeches are used for exactly this physiologic problem, decongesting tissue by inducing prolonged bleeding while venous neovascularization is established, so the abstract's timeline gives clinicians a realistic sense of how many days of decongestion such replants may require. The honest caveat: this paper studied a stab-incision-and-heparin technique, not leeches, so it informs the biological window for decongestion rather than validating leech therapy, and as a single-center retrospective series its timing figures are descriptive, not a controlled comparison.

Citation

The timing of neovascularization in fingertip replantation by external bleeding.

Han et al. · Plastic and reconstructive surgery, 2002

Added to ASH library: May 28, 2026 · Site last updated: June 18, 2026

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