American Society of Hirudotherapy

Successful local use of heparin calcium for congested fingertip replants

Observational published in Arch Plast Surg (2020)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Research reportClinical TrialsDrug DevelopmentKadota H et al. · Archives of plastic surgery, 2020

Abstract

BACKGROUND: Conventional methods of external bleeding for congested fingertip replants exhibit notable problems, including uncontrollable bleeding and unpredictable survival of the replant. We have added a local injection of heparin calcium to the routine use of systemic heparinization for inducing external bleeding. We retrospectively examined patients who underwent external bleeding using our method. METHODS: Local subcutaneous injections of heparin calcium were made in 15 congested replants in addition to systemic heparinization. Each injection ranged from 500 to 5,000 U. The average duration of the injections was 4.1 days. Surgical outcomes were analyzed and compared with a control group of patients who underwent external bleeding without heparin calcium. RESULTS: The overall survival rate was 93.3%, which was higher than that of the control group (83.3%), but the difference was not statistically significant (P=0.569). The survival rate for subzones I and II by the Ishikawa subzone classification was 100%, whereas it was 87.5% in subzones III and IV. No statistically significant difference was observed. The rate of partial necrosis was 0% in subzones I and II, whereas it was significantly higher (66.7%) in subzones III and IV (P=0.015). The mean total blood loss via external bleeding was 588 g in 10 fingers. No patients required blood transfusion. CONCLUSIONS: Congestion of a replanted fingertip can be successfully managed without blood transfusion by our method. Although complete relief from congestion in replants in subzones I and II is achievable, there is a higher risk of partial necrosis in subzones III and IV.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal Article

Summary

Series of 15 congested fingertip replants treated with local heparin calcium injection as a 'chemical leech' alternative; 93.3% survival rate with no blood transfusions required. Subzone IV cases had higher partial necrosis (66.7%).

Why This Matters for Hirudotherapy

This retrospective study examined local subcutaneous heparin calcium injections (500-5,000 U per injection, mean 4.1 days) added to systemic heparinization for inducing external bleeding in 15 congested fingertip replants. The survival rate was 93.3% (vs 83.3% control, NS), with 100% survival in Ishikawa subzones I-II but significantly higher partial necrosis (66.7%) in subzones III-IV; no transfusions were required. For ASH's domain, the relevance is indirect: the study addresses an alternative to leech therapy for managing venous congestion in digital replantation, a setting where leeches are commonly used. It does not involve leeches. The note should plainly state that no leeches or leech-derived agents were used, making this relevant only as comparative context for congestion management strategies that may compete with or complement hirudotherapy.

Citation

Successful local use of heparin calcium for congested fingertip replants.

Kadota H et al. · Archives of plastic surgery, 2020

Added to ASH library: May 27, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.