American Society of Hirudotherapy

Clinical use of leeches in reconstructive surgery

Research article published in American journal of orthopedics (Belle Mead, N.J.) (1997)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Narrative reviewClinical TrialsDaane et al. · American journal of orthopedics (Belle Mead, N.J.), 1997

Abstract

Although medicinal bloodletting with leeches is a practice that dates back 3500 years, leeches have been used in reconstructive surgery for only the past 35 years. In this article, the indications, mechanisms of action, and guidelines for using leeches in reconstructive surgery are reviewed.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal ArticleReview
Indexed MeSH termsAnimalsBlood CoagulationClinical ProtocolsEdemaHumansLeechesPatient SelectionReplantationSalivaSurgery, PlasticSurgical Flaps

Summary

Peer-reviewed clinical and outcomes research relevant to medicinal leech therapy and its biology. Indexed in PubMed and verified against the NCBI record.

Why This Matters for Hirudotherapy

This review summarizes the indications, mechanisms of action, and practical guidelines for using leeches in reconstructive surgery, noting that while medicinal bloodletting dates back roughly 3,500 years, surgical use of leeches spans only the prior ~35 years (as of publication). For ASH it is a useful orientation piece, situating modern leech therapy as a relatively recent application of an ancient practice and pointing to the salivary mechanisms that underlie its surgical role. As a narrative review it summarizes and interprets other work rather than reporting new primary data, so it should be read as expert synthesis, not as independent evidence of efficacy.

Citation

Clinical use of leeches in reconstructive surgery.

Daane et al. · American journal of orthopedics (Belle Mead, N.J.), 1997

Added to ASH library: May 28, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.