Management of Neonatal Aortic Thrombosis: Challenges and Outcomes With Systemic and Intra-arterial Thrombolysis.
Case report published in Cureus (2024)
Abstract
Neonatal aortic thrombosis, though rare, is associated with high mortality and is frequently linked to umbilical vessel catheterization, especially in smaller and critically ill infants due to their low levels of natural anticoagulants and increased prothrombotic activity. We report a case of a term neonate with abdominal aortic thrombosis and severe lower limb ischemia, presenting with respiratory distress requiring intubation and subsequent development of thrombosis by day 7. Initial anticoagulation with heparin proved insufficient, necessitating the use of reteplase and intra-arterial thrombolysis, which resulted in clinical improvement despite limited immediate success in Doppler studies. The patient was discharged on low-molecular-weight heparin against medical advice, highlighting the complexities and need for individualized management strategies in neonatal thromboembolism.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Summary
Neonatal aortic thrombosis, though rare, is associated with high mortality and is frequently linked to umbilical vessel catheterization, especially in smaller and critically ill infants due to their low levels of natural anticoagulants and increased prothrombotic activity. We report a case of a...
Why This Matters for Hirudotherapy
This case report describes a term neonate with abdominal aortic thrombosis and severe lower limb ischemia who was treated initially with heparin anticoagulation and subsequently with reteplase and intra-arterial thrombolysis after heparin proved insufficient. It is relevant to ASH's domain only in the broad context of anticoagulant and thrombolytic management of thrombotic disease—the therapeutic space in which hirudin-derived agents also operate. The abstract makes no reference to leeches, hirudotherapy, or hirudin. Its relevance is indirect, and as a single case report its findings are not generalizable.
Citation
Management of Neonatal Aortic Thrombosis: Challenges and Outcomes With Systemic and Intra-arterial Thrombolysis.
Reddy et al. · Cureus, 2024
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