American Society of Hirudotherapy

Pregnancy After Cardiac Surgery

Review published in Cureus (2022)

Last Updated: November 1, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Narrative reviewClinical LiteratureDrug DevelopmentMakhija et al. · Cureus, 2022

Abstract

Women with native heart valve disease who are considering getting pregnant should have a complete risk estimation to determine whether an intervention is required prior to becoming pregnant and, if so, to determine when it should be performed and what kind of surgical therapy will be used. Pregnancy is linked to early and late structural valve degeneration in women who have bioprostheses, suggesting a high reoperation rate. A mechanical valve during pregnancy increases the risk of maternal complications such as valve thrombosis and mortality. The claim that women with defective hearts should not become pregnant was driven by the high maternal death rate among cardiac patients who became pregnant. A preoperative anticoagulation therapy trial helped women scheduled for valve replacement to acquire complete information as to the choice of the prosthetic device. Integrated risk stratification scheme for pregnant patients with valvular heart disease, with WHO classification and an algorithmic approach to both preconception counseling and anticoagulation strategy as outlined here, as well as early referral to a cardiologist with expertise in the management of cardiac disease and pregnancy for these complex patients is recommended. However, in reality, some women present while pregnant and valve disease needs to be managed, balancing maternal outcome and fetal risk. In general, optimizing the hemodynamic situation of the mother is also beneficial to the fetus. However, cardiac surgery carries a high risk for the fetus. No anticoagulant regimen can be said to be entirely safe for use during pregnancy, as there is a degree of risk with each regimen. Therefore, this review has been done to find appropriate management for women dealing with such conditions.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal ArticleReview

Summary

This review outlines preconception risk assessment, prosthetic valve choice and anticoagulation strategy for pregnant patients with valvular heart disease, noting that no anticoagulant regimen can be considered entirely safe in pregnancy and recommending WHO-based risk stratification and early expert referral.

Context

This review examines pregnancy management in women with native or prosthetic heart valve disease, focusing on risk stratification and anticoagulation strategies during pregnancy. Anticoagulation is a central theme—the review discusses the risks of valve thrombosis with mechanical valves and notes that no anticoagulant regimen is entirely safe in pregnancy. The article does not mention leeches, hirudotherapy, hirudin, or any leech-derived agents.

Citation

Reference (Vancouver style)

Makhija N, Tayade S, Tilva H, Chadha A, Thatere U. Pregnancy After Cardiac Surgery. Cureus. 2022;14(11):e31133. doi:10.7759/cureus.31133. PMID: 36475179

Bibliographic details (authors, volume, pages, DOI) are taken from the PubMed record.

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