American Society of Hirudotherapy

Leech management before application on patient: a nationwide survey of practices in French university hospitals

Research article published in Antimicrobial resistance and infection control (2018)

Last Updated: March 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Clinical TrialsSafety & Infection ControlGrau D et al. · Antimicrobial resistance and infection control, 2018

Abstract

BACKGROUND: Leech therapy in plastic/reconstructive microsurgery significantly improves a successful outcome of flap salvage but the drawback is a risk of severe infection that results in a drop of the salvage rates from 70-80% to below 30%. We report the results of a national survey conducted in all the French university hospitals to assess the current extent of use of leech for medical practices in the hospital and to investigate maintenance, delivery practices and prevention of the risk of infection. METHODS: Data concerning conditions of storage, leech external decontamination, microbiological controls, mode of delivery and antibiotic prophylaxis were collected from all the French university hospitals in practicing leech therapy, on the basis of a standardized questionnaire. RESULTS: Twenty-eight of the 32 centers contacted filled the questionnaire, among which 23 practiced leech therapy, mostly with a centralized storage in the pharmacy; 39.1% of the centers declared to perform leech external decontamination and only 2 centers recurrent microbiological controls of the water storage. Leech delivery was mostly nominally performed (56.5%), but traceability of the leech batch number was achieved in only 39.1% of the cases. Only 5 centers declared that a protocol of antibiotic prophylaxis was systematically administered during leech therapy: either quinolone (2), sulfamethoxazole/trimethoprim (2) or amoxicillin/clavulanic acid (1). CONCLUSIONS: Measures to prevent infectious complications before application to patient have to be better applied and guidelines of good practices are necessary.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal Article
Indexed MeSH termsAmoxicillin-Potassium Clavulanate CombinationAnimalsAnti-Bacterial AgentsAntibiotic ProphylaxisCross InfectionDrug Delivery SystemsFranceHospitals, UniversityHumansLeechesLeechingMicrosurgery

Summary

Leech therapy in plastic/reconstructive microsurgery significantly improves a successful outcome of flap salvage but the drawback is a risk of severe infection that results in a drop of the salvage rates from 70-80% to below 30%.

Why This Matters for Hirudotherapy

Contributes clinical evidence for the therapeutic application of leech therapy.

Citation

Leech management before application on patient: a nationwide survey of practices in French university hospitals.

Grau D et al. · Antimicrobial resistance and infection control, 2018

Added to ASH library: March 18, 2026 · Site last updated: March 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.

Leech management before application on patient: a nationwide survey of practices in French university hospitals | ASH