American Society of Hirudotherapy

The Use of Medicinal Leeching in Breast Surgery: A Systematic Review

Systematic review published in J Clin Med (2024)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Narrative reviewClinical TrialsSafety & Infection ControlRajaram R et al. · Journal of clinical medicine, 2024

Abstract

Background: The medicinal leech has been used in plastic surgery to resolve venous congestion that can threaten the viability of tissue transfer. Within the context of breast surgery, venous congestion is a pertinent consideration for reconstructive and non-reconstructive breast surgery such as mammoplasty and mastopexy. However, leeching is closely associated with complications such as infection, pain, and anaemia. This is the first systematic review that examines the methodology, efficacy, and post therapeutic outcome data across all existing studies on medicinal leeching in breast surgery. Methods: A systematic search of PubMed and Embase databases from their inception to November 2023 was conducted. Inclusion criteria included studies reporting on the use of leeches to resolve venous congestion in any breast surgery. The JBI Critical Appraisal Checklist for Case Series tool was used for bias analysis. Descriptive statistics were undertaken in Microsoft Excel. Results: A total of 18 studies with a combined sample size of 28 were examined, including 4 case series and 14 case reports. Patients mostly underwent reconstructive breast surgery (75%). The median number of leeches used was two, with a median number of three leeching sessions per day and 3 days of leeching. Medicinal leeching successfully prevented the loss of 75% of all tissue transfers. The complication rate was high at 81.14% and mainly included infection and anaemia. Conclusions: Medicinal leeching is an effective method to relieve venous congestion in breast surgery but must be judiciously used within the clinical context of the patient to maximise efficacy and mitigate harm from complications.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal ArticleReview

Summary

Systematic review of 18 studies (28 patients) of medicinal leeching in breast surgery: 75% tissue salvage with high complication rate (81%) primarily infection and anaemia. Median 2 leeches/session, 3 sessions/day, 3 days total.

Why This Matters for Hirudotherapy

This systematic review examined 18 studies (4 case series, 14 case reports) totaling 28 patients who received medicinal leeching for venous congestion in breast surgery, with a median regimen of two leeches per session, three sessions daily, for three days. Leeching prevented loss of 75% of tissue transfers, but the complication rate was 81.14%, mainly infection and anemia. The review is directly relevant to ASH, providing aggregated evidence on leech therapy efficacy and morbidity in breast surgery specifically. The underlying evidence consists predominantly of case reports and small case series, and the total combined sample size is 28 patients.

Citation

The Use of Medicinal Leeching in Breast Surgery: A Systematic Review.

Rajaram R et al. · Journal of clinical medicine, 2024

Added to ASH library: May 27, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.