American Society of Hirudotherapy

Leech bites: massive bleeding, coagulation profile disorders, and severe anemia

Case report published in Am J Emerg Med (2008)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Case reportSafety & Infection ControlClinical TrialsKose A et al. · The American journal of emergency medicine, 2008

Abstract

Leeches have been in use for centuries, especially in plastic and reconstructive surgery wound and flap healing, in venous insufficiencies, and in the treatment of many disorders such as hemorrhoids and varicosity. With this study, we aimed to discuss coagulation disorder due to uncontrolled leech bites, consequent excessive skin hemorrhage, and anemia requiring blood transfusion. A 65-year-old male patient was referred to the emergency department because of excessive intractable bleeding that had occurred after leech bites. On physical examination, a total of 130 bites were detected on various regions of the body. In the laboratory findings of the patient, hemoglobin and hematocrit levels were extremely low, and prothrombin time, international normalized ratio, and partial thromboplastin time were markedly increased. The patient received a total of 8 units of fresh frozen plasma and 6 units of erythrocyte suspension. Bleeding stopped by decreasing after the transfusion of fresh frozen plasma. Although the complications due to leech injuries are rare, they may be an important cause of morbidity and mortality when an injury or prolonged bleeding in an internal region occurs. Prolonged skin hemorrhages rarely cause anemia, and deaths are caused by intractable hemorrhages. However, a coagulation disorder and consequent intractable hemorrhage have not been reported previously in the literature. In conclusion, it should be known that uncontrolled, blind, and excessive leech use causes severe hemorrhage and excessive blood loss, causing significant morbidity and mortality. Therefore, the awareness of either physicians or people using or recommending alternative medicine should be raised on this subject.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeCase ReportsJournal Article
Indexed MeSH termsAgedAnemiaAnimalsBites and StingsHemorrhageHumansLeechesMale

Summary

Case of 65-year-old male with 130 leech bites causing severe coagulation disorder and anemia requiring 8 units of fresh-frozen plasma and 6 units of erythrocyte suspension.

Why This Matters for Hirudotherapy

This case report documents a 65-year-old man referred for intractable bleeding after roughly 130 leech bites across the body, presenting with very low hemoglobin/hematocrit and markedly prolonged prothrombin time, INR, and partial thromboplastin time; bleeding was controlled only after transfusion of 8 units of fresh frozen plasma and 6 units of erythrocytes, and the authors note this combination of a coagulation disorder with consequent intractable hemorrhage from leech bites had not previously been reported. For hirudotherapy this is a cautionary safety reference: it shows that uncontrolled, excessive, non-clinical leech use can cause severe anemia and a coagulopathy requiring transfusion, supporting ASH's stance on limiting leech numbers, monitoring bleeding, and avoiding unsupervised application. The caveat is that this is a single extreme case driven by a very large number of bites administered outside proper clinical control, so it describes a worst-case hazard rather than the expected risk of appropriately dosed, supervised medicinal leeching.

Citation

Leech bites: massive bleeding, coagulation profile disorders, and severe anemia.

Kose A et al. · The American journal of emergency medicine, 2008

Added to ASH library: May 27, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.