American Society of Hirudotherapy

Intestinal flora of the medicinal leech Hirudinaria manillensis

Research article published in Journal of reconstructive microsurgery (1994)

Last Updated: March 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Clinical TrialsSafety & Infection ControlBickel K et al. · Journal of reconstructive microsurgery, 1994

Abstract

Medicinal leeches are widely used to treat venous congestion in microvascular surgery. Aeromonas hydrophila infection, following application of the leech species Hirudo medicinalis, is a recognized complication. Administration of antibiotics directed at Aeromonas has been successful in minimizing complications of infection from this organism. A different leech species, Hirudinaria manillensis, has recently been introduced for microsurgical use. A study of the enteric content of 30 of these leeches showed that Aeromonas hydrophila was isolated in only 20 percent of animals, while the majority of remaining positive cultures were single and mixed gram-negative rods. All organisms isolated were sensitive to current recommended coverage for Aeromonas hydrophila. This study suggests that the enteric flora of different leech species may be variable and should be carefully characterized, to direct appropriate prophylactic therapy prior to release of new species for clinical use.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal Article
Indexed MeSH termsAeromonasAnimalsCephalosporinsGram-Negative Bacterial InfectionsHumansIntestinesLeeches

Summary

Medicinal leeches are widely used to treat venous congestion in microvascular surgery. Aeromonas hydrophila infection, following application of the leech species Hirudo medicinalis, is a recognized complication.

Why This Matters for Hirudotherapy

Contributes clinical evidence for the therapeutic application of leech therapy.

Citation

Intestinal flora of the medicinal leech Hirudinaria manillensis.

Bickel K et al. · Journal of reconstructive microsurgery, 1994

Added to ASH library: March 18, 2026 · Site last updated: March 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.

Intestinal flora of the medicinal leech Hirudinaria manillensis | ASH