American Society of Hirudotherapy

Indications for replantation and factors that predict success

Review published in Eur J Orthop Surg Traumatol (2023)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Narrative reviewClinical TrialsBregman et al. · European journal of orthopaedic surgery & traumatology, 2023

Abstract

Since the advent of replantation techniques, there has been uneven progress in terms of success-even considering whether success is defined as continued perfusion of the digit or long term functional outcomes. Early enthusiasm and success have not been maintained despite increasing familiarity with microsurgical techniques and greater understanding of how to optimize outcomes for the individual components of replantation such as tendon repair, nerve repair, and osteosynthesis. Practitioners participating in the care of patients undergoing replantation should be familiar with the history and current understanding of both the indications and contraindications for the procedure, post-operative rehabilitation, and factors contributing to functional outcomes. A review of the literature from the first publications on the topic demonstrates evolution in practice and understanding of which patients should be indicated for replantation. Indications can be considered in three broad categories: injury factors, patient factors, and care context factors. These factors intersect with one another and can inform the surgeon pre-operatively regarding the most likely outcome for a given patient. This insight is critical to discuss pre-operatively with the patient in order to make a shared decision about how to manage their injury.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal ArticleReview
Indexed MeSH termsHumansReplantationAmputation, TraumaticFinger InjuriesTreatment OutcomeMicrosurgery

Summary

Review of replantation indications and predictive success factors for upper-limb amputation cases.

Why This Matters for Hirudotherapy

This review examines the evolution of indications and factors predicting success in replantation surgery, categorizing contributing factors into injury factors, patient factors, and care context factors. The abstract emphasizes the importance of shared decision-making between surgeon and patient regarding expected outcomes. For ASH's domain, the article has no defensible connection—leeches, hirudotherapy, and the leech secretome are not mentioned anywhere in the abstract. The review focuses on surgical indications, contraindications, postoperative rehabilitation, and functional outcomes, and provides no evidence regarding leech therapy or the leech secretome.

Citation

Indications for replantation and factors that predict success.

Bregman et al. · European journal of orthopaedic surgery & traumatology, 2023

Added to ASH library: May 27, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.