Hirunipin-2 — Second-Generation Leech Antimicrobial Peptide
Expanded characterization of hirunipin family with enhanced antimicrobial spectrum
Summary
Extended characterization of hirunipin-2, a second member of the hirunipin antimicrobial peptide family from Hirudo medicinalis. Features an expanded antimicrobial spectrum compared to the prototype, including activity against additional Gram-negative pathogens and enhanced biofilm penetration.
Why This Matters for Hirudotherapy
Demonstrates that the hirunipin AMP family contains multiple variants with potentially optimizable properties. The structural diversity within a single leech peptide family supports rational drug design approaches to engineering improved antimicrobial agents.
Citation
Novel Antimicrobial Peptides from Hirudo medicinalis — Hirunipins
Kumar et al. · Advanced Science (Wiley), 2025
Added to ASH library: March 18, 2026 · Site last updated: March 18, 2026