American Society of Hirudotherapy

Applications of leech therapy in medicine: a systematic review

Systematic review published in Frontiers in medicine (2024)

Last Updated: June 18, 2026Reviewed by: ASH Editorial Board
Research article — evidence reviewArticle reference
Evidence: Systematic reviewClinical TrialsHosseini M et al. · Frontiers in medicine, 2024

Abstract

BACKGROUND: Leech therapy (LT) is one of the most widely used treatment methods in traditional medicine. The present study aimed to systematically review clinical trials regarding the effects of LT on the prevention and healing of different diseases. METHODS: To identify all relevant published studies, we conducted a comprehensive search of PubMed, Scopus, and Web of Science databases without any temporal or geographical constraints until April 2023. To categorize the articles, five stages were considered. The PRISMA checklist and Cochran's bias analysis tool were used. RESULTS: In total, 12 trials that met the inclusion criteria were studied. The results of the studies showed that LT has had successful outcomes in treating different conditions. These included hormonal and metabolic complications, cardiovascular problems, and inflammatory-based diseases. CONCLUSION: "Leech therapy" is a traditional medical treatment used successfully to control and treat various conditions. Although this method can have complications, it is possible to benefit from this low-cost and low-complication treatment by taking preventive measures.

Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.

Publication typeJournal ArticleSystematic Review

Summary

Leech therapy (LT) is one of the most widely used treatment methods in traditional medicine. The present study aimed to systematically review clinical trials regarding the effects of LT on the prevention and healing of different diseases.

Why This Matters for Hirudotherapy

This systematic review examined clinical trials investigating leech therapy for the prevention and healing of various diseases, identifying 12 trials through a comprehensive search of three databases through April 2023. The review is directly relevant to hirudotherapy, reporting that included trials demonstrated successful outcomes across hormonal and metabolic complications, cardiovascular problems, and inflammatory-based conditions. The authors characterize leech therapy as a low-cost treatment with manageable complications when appropriate preventive measures are taken. However, the abstract provides only high-level summary conclusions without reporting specific outcome measures, effect sizes, results of the bias assessment, or details of individual trials, limiting the ability to evaluate the strength and consistency of the underlying evidence base from this abstract alone.

Citation

Applications of leech therapy in medicine: a systematic review.

Hosseini M et al. · Frontiers in medicine, 2024

Added to ASH library: March 18, 2026 · Site last updated: June 18, 2026

This website provides educational information and does not constitute medical advice, diagnosis, or treatment recommendations. Medicinal leech therapy carries clinically meaningful risks and should be performed only by qualified clinicians under institutionally approved protocols. FDA 510(k) clearance for medicinal leeches is limited to specific indications; investigational and off-label discussions are labeled accordingly. For patient-specific guidance, consult a qualified healthcare provider.