Smart Library

Faceted search across all 5 registries. Filter by registry type, evidence level, or safety domain.

Curated knowledge libraryReference collection

New to hirudotherapy? Start here

This library indexes the full evidence base. For orientation, begin with the core guides:

What is hirudotherapy?Conditions atlas Clinical evidence Patient guide

Filters

Registry

All Compounds Conditions RCTs Biographies Jurisdictions

Evidence level

All FDA-cleared context Systematic review Randomized controlled trial Cohort / case series Case report Preclinical In vitro Mechanistic

Safety domain

All Aeromonas infection Bleeding Anemia / transfusion Allergy / anaphylaxis Tissue failure Ocular risk Biohazard disposal

Showing 9 of 755 entries. Refine via URL query params.

RCTs

Low-Level Antimicrobials in the Medicinal Leech Select for Resistant Pathogens That Spread to Patients

GRADE very low

Beka L, Fullmer MS, Colston SM, Nelson MC, Talagrand-Reboul E, Walker P, Ford B, Whitaker IS, Lamy B, Gogarten JP, Graf J (2018) · mBio

Mechanistic

Hirudins and hirudin-like factors in Hirudinidae: implications for function and phylogenetic relationships

GRADE very low

Müller C, Haase M, Lemke S, Hildebrandt JP (2016) · Parasitology Research

Mechanistic

Diversity of hirudin and hirudin-like factor genes in the North-African medicinal leech, Hirudo troctina

GRADE very low

Ahmed RB, Abilov A, Müller C (2024) · Parasitology Research

Mechanistic

Monomeric and Oligomeric Decorsins of the Asian Medicinal Leech

GRADE very low

Tolksdorf C, Wolf R, Rauch BH, Jedlitschky G, Müller C (2025) · International Journal of Molecular Sciences

Mechanistic

Molecular Insights into Leech-Derived Bioactive Compounds: Biochemical Mechanisms and Therapeutic Potential

GRADE very low

Raghavi S, Deva Darshini B, Saravanan KM, Anbarasu K (2026) · International Journal of Molecular Sciences

Mechanistic

Novel Sodium Channel Inhibitor From Leeches

GRADE very low

Wang G, Long C, Liu W, Xu C, Zhang M, Li Q, Lu Q, Meng P, Li D, Rong M, Sun Z, Luo X, Lai R (2018) · Frontiers in Pharmacology

Mechanistic

In-depth profiles of bioactive large molecules in saliva secretions of leeches determined by combining salivary gland proteome and transcriptome data

GRADE very low

Liu Z, Tong X, Su Y, Wang D, Du X, Zhao F, Wang D, Zhao F (2019) · Journal of Proteomics

Mechanistic

Salivary transcriptome of the North American medicinal leech, Macrobdella decora

GRADE very low

Min GS, Sarkar IN, Siddall ME (2010) · Journal of Parasitology

Mechanistic

Microbiota Dynamics: A Key Factor in Hirudotherapy-Related Infections?

GRADE low

Karasartova D, Arslan-Akveran G, Sensoz S, Mumcuoglu KY, Taylan-Ozkan A (2025) · Microorganisms

Mechanistic