Smart Library

Faceted search across all 5 registries. Filter by registry type, evidence level, or safety domain.

Curated knowledge libraryReference collection

New to hirudotherapy? Start here

This library indexes the full evidence base. For orientation, begin with the core guides:

What is hirudotherapy?Conditions atlas Clinical evidence Patient guide

Filters

Registry

All Compounds Conditions RCTs Biographies Jurisdictions

Evidence level

All FDA-cleared context Systematic review Randomized controlled trial Cohort / case series Case report Preclinical In vitro Mechanistic

Safety domain

All Aeromonas infection Bleeding Anemia / transfusion Allergy / anaphylaxis Tissue failure Ocular risk Biohazard disposal

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Conditions

Metabolic Syndrome (Investigational Adjunct)

Tier C

Investigational adjunct to lifestyle modification in metabolic syndrome; no clinical study in metabolic syndrome identified; weight loss, dietary modification, and pharmacotherapy remain primary.

InvestigationalPreclinical (animal)

Non-Alcoholic Fatty Liver Disease (Investigational Adjunct)

Tier C

Investigational adjunct in NAFLD/MASLD; no human clinical study identified; weight loss, dietary modification, and resmetirom remain primary.

InvestigationalPreclinical (animal)

Vascular Cognitive Impairment (Highly Investigational)

Tier C

Highly investigational; no clinical study of leech therapy with cognitive outcomes was identified; vascular risk-factor management (BP, lipids, antiplatelet, lifestyle) remains primary.

InvestigationalPreclinical (animal)