Smart Library
Faceted search across all 5 registries. Filter by registry type, evidence level, or safety domain.
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Evidence level
Showing 8 of 755 entries. Refine via URL query params.
Conditions
8Peripheral Artery Disease (Claudication, Investigational)
Tier CHighly investigational adjunct for intermittent claudication; ABI must be assessed first; critical limb ischemia is an absolute contraindication.
Complex Regional Pain Syndrome (Type I, Investigational)
Tier CHighly investigational adjunct for CRPS Type I; one case report and no controlled study identified; multidisciplinary pain management and physiotherapy remain primary.
Hidradenitis Suppurativa Hurley Stage II (Investigational Adjunct)
Tier CInvestigational adjunct in Hurley Stage II HS refractory to conventional therapy; the only clinical report found describes harm; biologics (adalimumab, secukinumab) and surgical management remain primary.
Chronic Radiation Dermatitis (Investigational)
Tier CHighly investigational adjunct for chronic radiation dermatitis after oncology completion; no clinical report of leech therapy was identified; standard skin care and dermatology referral remain primary.
Complex Regional Pain Syndrome Type I (Investigational Adjunct)
Tier CHighly investigational adjunct for CRPS-I in patients with stable nutritional vascular status; a single case report only; multidisciplinary pain management remains primary.
Chronic Mid-Portion Achilles Tendinopathy (Investigational)
Tier CInvestigational adjunct for chronic mid-portion (non-insertional) Achilles tendinopathy; eccentric loading remains evidence-based first-line.
Livedoid Vasculopathy (Investigational Adjunct)
Tier CInvestigational adjunct for livedoid vasculopathy; no clinical leech study was identified, and anticoagulation and IVIG remain guideline first-line.
Necrobiosis Lipoidica (Investigational Adjunct)
Tier CInvestigational adjunct for stable non-ulcerated necrobiosis lipoidica; no clinical leech study was identified; topical corticosteroids remain first-line.