Bloodsucking Leech FBN1 / GLB3 Expansion (Comparative)
Expanded FBN1 (fibrillin-1) + GLB3 (globin-3) gene families across H. nipponia / H. manillensis vs W. pigra — Zheng 2023 functional-genomic comparison.
Preclinical / mechanisticLast updated: 2026-05-28 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Expanded FBN1 (fibrillin-1) + GLB3 (globin-3) gene families across H. nipponia / H. manillensis vs W. pigra — Zheng 2023 functional-genomic comparison.
- Evidence level
- Mechanistic discussion
- Drug vs leech
- Purified natural compound
Clinical translation limit
FBN1 / GLB3 expansion is a comparative-genomics finding with no direct human therapeutic translation. No FDA-approved derivative.
Molecular Profile
- Category
- Other
- Evidence tier
- Preclinical
- Source species
- H. nipponia + H. manillensis vs W. pigra
- Discovered
- 2023 · Zheng J et al.
Biological Targets
- → FBN1: rapid post-feeding body swelling; GLB3: long-term blood storage in leech midgut
Key Citations
- Zheng J et al. (2023), Gigascience · PMID 37039117
External Resources
Related Other Compounds
Granulin (leech-derived)
Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.
Leech VEGF Modulator
Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.
Leech PDGF Modulator
Platelet-derived growth factor pathway modulator — implications for wound-healing.
Leech Granulin-A
Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).