Leech Extract Anti-Atherosclerotic (2020 Review)
Review synthesising leech-extract anti-atherosclerotic pharmacological mechanisms across animal + cell models — Eldor 2019.
Preclinical / mechanisticLast updated: 2026-05-28 · Reviewed by ASH Editorial Board
Mechanistic Evidence Box
Preclinical / mechanistic- Page type
- Compound profile
- Evidence type
- Review synthesising leech-extract anti-atherosclerotic pharmacological mechanisms across animal + cell models — Eldor 2019.
- Evidence level
- Expert consensus
- Drug vs leech
- Leech-derived crude extract
- Safety domains
- Bleeding
Clinical translation limit
Review evidence does NOT establish clinical efficacy for atherosclerosis prevention or treatment. Atherosclerosis is not an FDA-cleared K040187 indication.
Molecular Profile
- Category
- Other
- Evidence tier
- Preclinical
- Source species
- Hirudo medicinalis (composite)
- Discovered
- 2019 · Eldor A et al.
Biological Targets
- → platelet aggregation; endothelial inflammation; fibrinogen; serum lipids
External Resources
Related Other Compounds
Granulin (leech-derived)
Growth factor and wound-healing modulator — promotes angiogenesis and tissue regeneration.
Leech VEGF Modulator
Vascular endothelial growth factor pathway modulator — angiogenic and wound-healing implications.
Leech PDGF Modulator
Platelet-derived growth factor pathway modulator — implications for wound-healing.
Leech Granulin-A
Granulin-family peptide identified in Hirudo medicinalis — putative growth-factor / wound-healing analog (mechanistic only).